Extended Reality (XR) and Human Computer Interaction (HCI) have been covered quite a bit in NBT events the last few years. This fireside chat will focus on what is coming beyond the typical five (5) year technology horizon. XR and HCI are often discussed as mature areas of research and implementation, while in reality they are in their infancy. This group of experts from industry, academic, and government will discuss the next major advancements coming, the technological challenges that exist, and the barriers to adoption that must be addressed to move these fields into the next decade and more.