This TalX will explore the co-dependency between the Data Mesh and Zero Trust and their intersection with MS&T. We will discuss the strategic need, emphasizing the rapid change in technology. For example, the fear that quantum computing, with a horizon of about 3-4 years hence, is the first technology able to break traditional encryption methods. Other examples are the ability for LLMs and other bots to perform rapid, nearly undiscernible security attack and the increased need for scalable, real-time security measures that are flexible and trustworthy as the data mesh adoption enables collaboration while needing to protect their Intellectual Property.