This TalX will discuss the evolving requirements, challenges and opportunities as simulation is now used to enable humans to prepare for missions alongside autonomous systems, as well as train the autonomous systems to get them ready for the future fight. Considering the different abilities of humans and machines to go beyond visual and leverage additional signals and spectral bands, or the speed with which each participant can go through a simulation or training plan and how to harmonize these discrete requirements come to the forefront, as will the need to consider new testing and validation.