Given the ongoing explosion of Augmented, Virtual, and Mixed Reality technologies and tools, we continue to see instances where we need to pay special attention to human-centered issues in developing and using these technologies in practical applications. Our panel focuses on continuing challenges in developing and applying these technologies for human performance and readiness. There are many opportunities, but there are also technological gaps and risks that persist. Examples include cybersickness and fatigue, environmental constraints such as outdoor implementation or applications in secure spaces, precision in activity tracking for individuals and larger teams in a variety of real-world contexts and situation, haptics, and how best to get realistic interaction and feedback with the environment at hand (sorry, no pun intended). The audience will have the opportunity to connect with a group of multi-national innovators who are driving research and applications with these technologies and who are also working to address some of the gaps we see today. Event participants will also have a chance to hear about panel member’s ongoing research and developments, their successes and the things that are continuing challenges for their work. Audience members will also come away with a much better understanding where a number of communities are in their state of the art and what they are doing to improve human interaction, learning, and immersion in these environments.