Military and civilian healthcare is undergoing radical transformations in almost every aspect of patient care from diagnosis to treatment. Along with increased complexity in the technology of delivery systems and procedures, medical knowledge is expanding at an ever-increasing rate, and yet clinicians are expected to retain knowledge and remain proficient in their fields. Frequency of exposure to specific clinical problems and processes are known contributors to physicians’ decay of clinical knowledge and proficiencies. For example, while deployed, military physicians may experience less demand for specific clinical skills and are, therefore, at risk for knowledge decay. A systematically applied knowledge retention program integrated with continuous training is one possible response. However, institutionalizing standardized training at fixed intervals for all may not be the most cost-effective nor efficient solution. This paper discusses the progress of a research study tasked to develop and validate efficient interventions to mitigate physician knowledge decay that address both increased domain complexity and lower frequencies of exposure. The process of intervention selection is based on the analysis of elements of the care for nine targeted clinical problems that reveal physician knowledge decay with decreasing frequency of exposure to those clinical problems. Once the most critical elements of the care process have been identified, we apply a structured approach for selecting, developing, and evaluating possible interventions geared towards choosing those that specifically address identified knowledge needs and align with the organization’s learning goals, infrastructure and operating budgets. Recommendations for a systematic, yet flexible, method for evaluating, weighing and scoring multiple knowledge decay mitigation alternatives are included, supporting interventions ranging from static job aids to immersive learning simulations. In summary, this paper proposes a comprehensive selection model for continuing medical education programs committed to prevent skill decay, aid knowledge retention and improve overall physician and organizational performance.