Offering laboratories and team projects present significant challenges for delivering Science, Technology, Engineering, and Mathematics (STEM) courses in the online (asynchronous) modality. These interactive workspaces are important attributes since they provide forums for students to more deeply explore fundamental principles, exercise teamwork and planning to jointly overcome problems, and gain critical experience. The employment of online environments and interactive activities hold the potential to change how fundamental student outcomes measured by accreditation organizations are incorporated and treated in curricula, potentially improving the quality of the overall educational experience. To address this need Embry-Riddle Aeronautical University has teamed with Pinnacle Solutions to develop a realistic unmanned aircraft system (UAS) development, application, and evaluation simulation that educators can integrate into program curriculum. The research contained in this paper addresses simulation development and application starting with identification of basic educational objectives driving the need and how the simulation tool is envisioned to satisfy learning objectives. This will be followed by a description and examples of a multi-environment simulation framework designed to meet those needs. The first is a component test environment where students can investigate basic technical principles of operation and key performance metrics of standalone UAS components such as sensors, communications, and propulsion elements. The second is an integration facility, where students are provided the capability to apply knowledge gained in the previous laboratory to select and combine appropriate elements into a unified subsystem to meet prescribed mission parameters. The third is a flight test environment, where students experiment with development and execution of simulated flight profiles over common terrain environments (i.e., mountainous) to measure operational performance attributes of the completed UAS. The design is anticipated to provide the flexibility to implement each environment sequentially, as described above, or independently; ensuring a solution applicable to a broad range of courses, objectives, outcomes, and student capabilities.