Recognizing the value of systems engineering (SE) as a key enabler of successful systems acquisition, and the growing importance of systems interdependencies affecting the ability for mission success of highly complex development systems, the Deputy Under Secretary of Defense for Acquisition and Technology developed the [2008] “Systems Engineering Guide for Systems of Systems.â€� While this guide provides excellent insight into the Systems of Systems (SoS) environment, as well as core SoS SE elements, the process to apply them in a DoD acquisition environment is not included. The purpose of this paper is to extend those concepts by defining a system of system acquisition process from receipt of modeling and simulation (M&S) needs through to development of individual requirements for the constituent systems by leveraging the power of Model Based Systems Engineering (MBSE) practices. Because it's not atypical for constituent developers to read the same need statement and interpret what occurs and what is needed on opposite sides of an interface differently, severe issues can result of which are not discovered until the resolution is extremely costly. The use of MBSE and the Systems Modeling Language (SysML) provides formal methods and notations that can remedy SoS misunderstandings prior to development. Further, our proposed process will facilitate collaboration amongst the system constituents and other stakeholders using MBSE throughout the acquisition process will create a shared common understanding and agreement for the efforts required for success of the SoS mission. Included in the discussion of the proposed acquisition process will be conceptual modeling, architecture and design reviews. The nature of DoD missions and the simulations that describe them are becoming more complex with increasing interdependence among the systems involved. This paper intends to provide the practitioner with systems engineer processes that will result in avoidance of the unintended consequences impacting mission success.