Over the past decade, the U.S. Marine Corps has shifted its training focus towards enabling effective and efficient decision making in its small unit leaders. Small unit leaders with relatively little experience are increasingly required to make tactical decisions with critical second and third order effects. These near strategic level decisions are not being made in a Command Operations Center (COC), but in the heat of the battle, where the decision maker is surrounded by high levels of physical and emotional stress. Studies have shown significant adverse effects of combat stressors on cognitive performance (Lieberman et al., 2005) as well as persistent changes in brain functional connectivity (Van Wingen et al., 2012). To ensure military success, and the health and wellness of our veterans, it is critical that these small unit leaders receive training necessary to develop strategies which enable them to make effective decisions under stress and mitigate long term physiological and psychological impacts of stress. However, a challenge with implementing such training in the military is the ability to induce high enough levels of stress to elicit physiological and psychological responses similar (maybe not in magnitude, but in nature) to those experienced in combat. Simulation-based training provides a less resource-intensive alternative to live exercises and greater opportunity for variation in decision dilemmas, situations, and stressors. Unfortunately, there is little empirically-validated guidance on how to utilize simulation to train decision making under stress. An approach for integrating cognitive, emotional, and socio-evaluative stressors into simulation-based training was developed and evaluated in a study conducted with experienced Marines. The results found significant increases in both physiological stress response (i.e., increased electrodermal activity), and perceived stress (i.e., State Trait Anxiety Index responses) during this simulationbased training approach, suggesting the method may be an effective means of inducing stress in experienced Warfighters.