Homeland security stakeholders, who acquire and use M&S capabilities, include all the major components of the U. S. Department of Homeland Security (DHS): Customs and Border Protection (CBP), Citizenship and Immigration Services (CIS), Federal Emergency Management Agency (FEMA), Immigration and Custom Enforcement (ICE), Transportation Security Agency (TSA), U.S. Coast Guard (USCG), and U.S. Secret Service (USSS). Other developers and users of M&S tools and data include state, tribal, and local homeland security agencies, homeland security training facilities, exercise participants, systems and tool developers, and academic researchers. Other stakeholders include non-governmental organizations (NGOs) and international organizations with homeland security missions or concerns. This paper describes a meta-model for analyzing natural and man-made threats and hazards, which considers integration of capabilities from multiple consortiums of public and private sector organizations. The social and physical impacts of natural and man-made disasters can be analyzed using irregular warfare modeling capabilities to provide insights on political, military, economic, society, information, infrastructure (PMESII) domains to support problem solving, decision making, and training at multiple levels of the enterprise. This meta-model provides a framework for assessing current capabilities to identify needs and advance the state-of-the-art of M&S for homeland security.