DoD Instruction 5000.2 presents human systems integration (HSI-formerly MPTS) guidance for all services and industry to follow. The Army's manpower and personnel integration (MANPRINT) process tailored for simulation, instrumentation, and training device RD&A provides a roadmap for fulfilling HSI requirements. Process goals focus on fielding devices that users can effectively and safely operate and maintain while performing tasks according to standards under given conditions. The purpose of this paper is to present a MANPRINT roadmap in terms that assist program administrators and specialists (Human factors and safety engineers, logisticians, et al.) in executing their HSI responsibility and authority. Innovative methods used for making HSI/MANPRINT work productively in the simulation, instrumentation, and training device RD&A environment are discussed.